Understanding how certain immune cells protect the intestines from infections
Differentiation and function of intestinal tissue-resident memory T cells
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-10904896
This study is looking at special immune cells in the intestines that help your body quickly fight off infections, and it aims to understand how these cells work so we can improve protection against germs like Yersinia pseudotuberculosis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-10904896 on ClinicalTrials.gov |
What this research studies
This research investigates the role of tissue-resident memory T cells (Trm) in the intestines, which are crucial for rapid immune responses to infections. By studying how these cells are generated and maintained, the research aims to uncover their unique characteristics and functions in protecting against pathogens like Yersinia pseudotuberculosis. The approach involves examining the behavior of these immune cells in the intestinal tissue during infection, focusing on their differentiation and response mechanisms. This could lead to insights into enhancing immune protection in the gut.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of intestinal infections or those at risk for such infections, particularly those with weakened immune systems.
Not a fit: Patients who do not have any history of intestinal infections or those with fully functioning immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve strategies for preventing and treating intestinal infections, particularly in individuals with compromised immune systems.
How similar studies have performed: Other research has shown promising results in understanding the role of tissue-resident memory T cells in various infections, indicating that this approach has potential for success.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BERGSBAKEN, TESSA — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: BERGSBAKEN, TESSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus