Understanding how certain immune cells protect against malaria
Role of cytolytic ZEB2+ memory CD4+ T cells in protection against liver stage malaria
['FUNDING_R21'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11143463
This study is looking at how certain immune cells in your blood help protect against malaria in the liver, and it's for people living in areas where malaria is common, with the hope that what we learn can help create better vaccines.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11143463 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific memory CD4+ T cells in providing protection against the liver stage of malaria. By analyzing blood samples from individuals in malaria-endemic regions, the study aims to identify the cellular immune responses that contribute to long-lasting immunity. The researchers will utilize advanced techniques like high dimensional flow cytometry and single cell transcriptomics to gain insights into how these immune cells function. This understanding could lead to the development of more effective malaria vaccines.
Who could benefit from this research
Good fit: Ideal candidates for this research include children under 11 years old living in malaria-endemic regions who have been exposed to the malaria parasite.
Not a fit: Patients who do not live in malaria-endemic areas or those who have not been exposed to malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the creation of more effective malaria vaccines, significantly reducing the incidence and severity of malaria in vulnerable populations.
How similar studies have performed: Previous research has shown promise in understanding immune responses to malaria, but this specific approach using advanced cellular analysis techniques is relatively novel.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAUVAU, GREGOIRE STEPHANE — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: LAUVAU, GREGOIRE STEPHANE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.