Understanding how certain immune cells produce antibodies
Official title: Regulation of Natural Antibody-Producing B-1 Cells
Funded at Johns Hopkins University · NIH-11088871 · Data updated 2026-11-12
This study is looking at special immune cells called B-1 cells to understand how they make natural antibodies, especially in people with a rare genetic disorder that affects antibody production, and it hopes to find new ways to help manage autoimmune diseases and infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 14, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $238,256 |
| NIH project number | 5R21AI172208-02 |
| Project ID | NIH-11088871 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune diseases or those with a rare genetic disorder affecting antibody production.
✕Less likely to help
Patients with non-autoimmune conditions or those without any genetic predisposition to antibody production issues may not benefit from this research.
What this research studies
This research investigates the role of specific immune cells, known as B-1 cells, in producing natural antibodies, particularly in the context of a rare genetic disorder that affects antibody production. The study focuses on how these cells develop during early life and how their unique characteristics contribute to autoimmune responses and susceptibility to infections. By examining the pathways and mechanisms that control these cells, the research aims to uncover potential therapeutic targets for managing autoimmune diseases. Patients may benefit from insights that could lead to new treatments or preventive strategies for autoimmune conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for autoimmune diseases by enhancing our understanding of antibody production.
How similar studies have gone: Previous research has shown promising results in understanding B cell functions and their role in autoimmunity, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Baumgarth, Nicole — Johns Hopkins University
- Study coordinator: Baumgarth, Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.