Understanding how certain immune cells hide chronic infections
Characterizing Macrophages as "Hide-Outs" for Chronic Pathogens
This study is looking at how certain immune cells can hide and protect chronic infections like HIV and tuberculosis, with the goal of finding new ways to help the immune system fight these infections better for people living with these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11140185 on NIH RePORTER |
What this research studies
This research investigates how macrophages, a type of immune cell, can harbor chronic pathogens like HIV and Mycobacterium tuberculosis, allowing them to evade the immune system. The study aims to uncover the mechanisms that enable these infected macrophages to resist destruction by immune cells such as T cells and natural killer (NK) cells. By identifying these pathways, the research seeks to find ways to enhance the immune response against these hidden infections, potentially leading to better treatment strategies for patients with chronic diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with chronic infections such as HIV or tuberculosis.
Not a fit: Patients without chronic infections or those with acute infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with chronic infections, enhancing their immune response and potentially reducing disease persistence.
How similar studies have performed: Previous research has shown promise in targeting immune evasion mechanisms in chronic infections, suggesting that this approach could yield significant advancements.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Clayton, Kiera L. — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Clayton, Kiera L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.