Understanding how certain immune cells help reduce inflammation in heart disease
Novel mechanisms for the generation of resolving monocytes
['FUNDING_R01'] · VIRGINIA POLYTECHNIC INST AND ST UNIV · NIH-11049148
This study is looking at how certain immune cells can help reduce inflammation in atherosclerosis, a condition that can cause heart problems, and aims to find new ways to improve treatments for people dealing with this issue.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA POLYTECHNIC INST AND ST UNIV (nih funded) |
| Locations | 1 site (BLACKSBURG, UNITED STATES) |
| Trial ID | NIH-11049148 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific immune cells, known as resolving monocytes, in reducing inflammation associated with atherosclerosis, a condition that can lead to heart disease. The study focuses on understanding the mechanisms that allow these cells to effectively clean up debris and promote healing within blood vessels. By using animal models, researchers aim to identify new therapeutic targets that could enhance the function of these monocytes, potentially leading to better treatments for patients with atherosclerosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with atherosclerosis or related cardiovascular conditions.
Not a fit: Patients without atherosclerosis or those with conditions unrelated to inflammation in cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart health by reducing inflammation and preventing the progression of atherosclerosis.
How similar studies have performed: Previous research has shown promise in understanding immune cell functions in inflammation, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
BLACKSBURG, UNITED STATES
- VIRGINIA POLYTECHNIC INST AND ST UNIV — BLACKSBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, LIWU — VIRGINIA POLYTECHNIC INST AND ST UNIV
- Study coordinator: LI, LIWU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.