Understanding how certain immune cells help reduce eye inflammation
Resolution of ocular inflammation: the role of type 1 conventional dendritic cells
This study is looking at how certain immune cells help reduce eye inflammation in people with non-infectious uveitis, with the hope of creating more personalized treatments that work better and have fewer side effects for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11124261 on NIH RePORTER |
What this research studies
This research investigates the role of type 1 conventional dendritic cells in resolving ocular inflammation, specifically in non-infectious uveitis. By using advanced techniques like single cell RNA sequencing, the study aims to classify different subtypes of uveitis and understand how variations in these immune cells affect the condition. The goal is to develop more effective, personalized treatment strategies that minimize side effects and improve patient outcomes. Patients may benefit from a more tailored approach to managing their eye inflammation based on their unique immune profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-infectious uveitis, particularly those who have not responded well to standard treatments.
Not a fit: Patients with infectious causes of uveitis or those without ocular inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients suffering from ocular inflammation, potentially preserving their vision.
How similar studies have performed: Similar research approaches using molecular characterization and immune profiling have shown promise in other inflammatory conditions, suggesting potential for success in this area as well.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Hassman, Lynn M — University of Colorado Denver
- Study coordinator: Hassman, Lynn M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.