Understanding how certain immune cells help protect against influenza
B-1 cells, IgM and Protective Humoral Immunity to Influenza
This study is looking at how certain immune cells called B-1 cells help make antibodies that can protect us from the flu, and it’s for anyone interested in understanding how our bodies fight off different flu viruses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10694180 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, known as B-1 cells, and their production of natural IgM antibodies in providing protection against influenza viruses. By studying both human responses and animal models, the research aims to identify how these immune components contribute to reducing the severity of influenza infections. The methodology includes analyzing immune responses in various settings to determine the effectiveness of these antibodies in combating different strains of the virus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of severe influenza infections, such as the elderly or those with compromised immune systems.
Not a fit: Patients who have already been vaccinated against influenza and have no history of severe reactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines or therapies that enhance immune protection against influenza.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to influenza, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Baumgarth, Nicole — Johns Hopkins University
- Study coordinator: Baumgarth, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.