Understanding how certain immune cells help prevent autoimmune diseases in newborns
Aire-dependent thymic B-1a cells play a key role in neonatal tolerance induction
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11060957
This study is looking at how a special type of immune cell called CD5+ B-1a cells helps newborns develop a healthy immune system that can prevent autoimmune diseases, and it aims to find ways to use this knowledge to help treat those conditions later on.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11060957 on ClinicalTrials.gov |
What this research studies
This research investigates the role of CD5+ B-1a cells, a type of immune cell, in the development of self-tolerance during the neonatal period. It focuses on how these cells interact with T cells in the thymus to promote the generation of regulatory T cells, which are crucial for preventing autoimmune responses. The study employs advanced techniques to analyze the signaling pathways and cellular interactions involved in this process, aiming to uncover mechanisms that could be targeted for therapeutic purposes in autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with autoimmune conditions or those at risk of developing such disorders.
Not a fit: Patients who do not have autoimmune diseases or are not at risk for these conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing autoimmune diseases by enhancing the body's ability to maintain self-tolerance.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in tolerance and autoimmunity, suggesting that this approach could yield valuable insights.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HERZENBERG, LEONORE A. — STANFORD UNIVERSITY
- Study coordinator: HERZENBERG, LEONORE A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.