Understanding how certain immune cells help heart transplants survive
Requirements and mechanisms of alloantigen-induced cardiac allograft survival by cDC1s
['FUNDING_FELLOWSHIP'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10912043
This study is looking at how certain immune cells can help heart transplants last longer and be accepted by the body, which could mean less need for medications that suppress the immune system for people who receive heart transplants.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10912043 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific immune cells, known as conventional dendritic cells type 1 (cDC1s), in promoting the survival of heart transplants. By exploring how these cells interact with the immune system, the study aims to identify new strategies to enhance the acceptance of transplanted hearts and reduce the need for long-term immunosuppressive medications. The approach involves examining the mechanisms by which cDC1s contribute to immune tolerance, potentially leading to better outcomes for transplant recipients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are undergoing or have undergone heart transplantation.
Not a fit: Patients who are not candidates for heart transplantation or those with other significant comorbidities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart transplant survival rates and reduced complications from immunosuppressive therapy.
How similar studies have performed: Previous research has shown promise in understanding the role of immune cells in organ transplantation, suggesting that this approach could yield significant insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHROTH, SAMANTHA LEIGH — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: SCHROTH, SAMANTHA LEIGH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.