Understanding how certain immune cells help fight tumors
Official title: The Tumor Microenvironment Niche of Type I conventional Dendritic Cells
Funded at University of California, San Francisco · NIH-11089491 · Data updated 2026-11-12
This study is looking at how certain immune cells help fight tumors, with the hope of finding ways to make cancer treatments work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | June 21, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $531,064 |
| NIH project number | 5R01CA197363-08 |
| Project ID | NIH-11089491 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with various types of cancer who are seeking innovative treatment options.
✕Less likely to help
Patients with non-cancerous conditions or those who do not have an active tumor may not benefit from this research.
What this research studies
This research investigates the immune system's response to tumors, focusing on specific immune cells called dendritic cells and their interactions with T cells. The study aims to identify the cellular and molecular components that enhance the effectiveness of immunotherapies. By using advanced techniques like spatial transcriptomics and genetic tools, researchers will explore how these immune cells organize and support tumor-fighting activities. The goal is to better understand and potentially engineer environments that promote tumor clearance.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapy strategies that enhance the body's ability to fight cancer.
How similar studies have gone: Previous research has shown promise in understanding immune responses in tumors, making this approach both innovative and building on established findings.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Krummel, Matthew F — University of California, San Francisco
- Study coordinator: Krummel, Matthew F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.