Understanding how certain immune cells help fight tumors
The Tumor Microenvironment Niche of Type I conventional Dendritic Cells
This study is looking at how certain immune cells help fight tumors, with the hope of finding ways to make cancer treatments work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11089491 on NIH RePORTER |
What this research studies
This research investigates the immune system's response to tumors, focusing on specific immune cells called dendritic cells and their interactions with T cells. The study aims to identify the cellular and molecular components that enhance the effectiveness of immunotherapies. By using advanced techniques like spatial transcriptomics and genetic tools, researchers will explore how these immune cells organize and support tumor-fighting activities. The goal is to better understand and potentially engineer environments that promote tumor clearance.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who are seeking innovative treatment options.
Not a fit: Patients with non-cancerous conditions or those who do not have an active tumor may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapy strategies that enhance the body's ability to fight cancer.
How similar studies have performed: Previous research has shown promise in understanding immune responses in tumors, making this approach both innovative and building on established findings.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Krummel, Matthew F — University of California, San Francisco
- Study coordinator: Krummel, Matthew F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.