Understanding how certain immune cells help fight parasitic infections.
The Origin and Role of Pulmonary ILC2 Subsets in Anti-Helminth Immunity
This study is looking at how certain immune cells help the body fight off infections from parasites found in soil, and it aims to learn more about how these cells work and move in the lungs, which could lead to better treatments for people dealing with these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10903966 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, known as group 2 innate lymphoid cells (ILC2), in the body's response to parasitic infections caused by soil-transmitted helminths. The study aims to uncover how these cells originate, migrate to the lungs, and interact with other immune cells during infection. By exploring the distinct types of ILC2 cells and their functions, the research seeks to fill critical gaps in our understanding of how the immune system can effectively clear these parasites. Patients may benefit from insights that could lead to improved treatments for helminth infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are infected with soil-transmitted helminths or are at high risk of such infections.
Not a fit: Patients who do not have a history of helminth infections or related immune response issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the immune response against parasitic infections, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to parasitic infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Reinhardt, Richard Lee — National Jewish Health
- Study coordinator: Reinhardt, Richard Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.