Understanding how certain immune cells help fight influenza
Official title: Monocyte-derived galectin-1 promotes tissue-resident memory T cell response
Funded at University of Rochester · NIH-11017395 · Data updated 2026-11-12
This study is looking at how certain immune cells help protect us from the flu and how a specific protein might boost their response, with the goal of creating better vaccines to keep you safe from the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | November 22, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $722,958 |
| NIH project number | 1R01AI187088-01 |
| Project ID | NIH-11017395 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of influenza infection, particularly those with weakened immune systems or chronic respiratory conditions.
✕Less likely to help
Patients who are not at risk for influenza or those who have already received effective vaccinations may not benefit from this research.
What this research studies
This research investigates how specific immune cells, known as tissue-resident memory T cells, respond to influenza infections in the respiratory tract. The study aims to understand the role of monocyte-derived galectin-1 in promoting these immune responses, which are crucial for long-term protection against the virus. By exploring the tissue microenvironment and its effects on these immune cells, the research seeks to improve vaccine strategies that can enhance immunity at the site of infection. Patients may benefit from insights that could lead to more effective vaccines against influenza.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines that provide long-lasting protection against influenza.
How similar studies have gone: Previous research has shown promise in enhancing immune responses through targeted vaccine strategies, suggesting potential success for this approach.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Kim, Minsoo — University of Rochester
- Study coordinator: Kim, Minsoo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.