Understanding how certain immune cells help fight cancer
Sustaining Tissue Resident Memory T cells
This study is looking at how special immune cells called tissue-resident memory T cells help our bodies remember and fight off melanoma, a type of skin cancer, and it aims to find ways to make these cells work better for longer-lasting protection against the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10995330 on NIH RePORTER |
What this research studies
This research investigates how tissue-resident memory T cells (TRM) contribute to long-lasting immunity against cancer, particularly melanoma. By using a mouse model that mimics human melanoma patients, the study aims to uncover mechanisms that allow these immune cells to persist in tissues and respond effectively to tumors. The researchers will explore the role of specific immune cell interactions in maintaining TRM cells and their function in tumor immunity, which could lead to new strategies for enhancing cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are melanoma patients, especially those who have developed vitiligo as a result of their treatment.
Not a fit: Patients with cancers other than melanoma or those who do not have a history of immune checkpoint inhibitor treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies that harness the body's immune system to provide long-lasting protection against tumors.
How similar studies have performed: Previous studies have shown promising results in understanding the role of TRM cells in cancer immunity, indicating that this approach has potential for significant advancements.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Huang, Yina Hsing — Dartmouth College
- Study coordinator: Huang, Yina Hsing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.