Understanding how certain immune cells help control lung inflammation during flu infections
Markers and regulation of regulatory CD8+ T cells during influenza-induced lung immunopathology
['FUNDING_R01'] · LOUISIANA STATE UNIV A&M COL BATON ROUGE · NIH-10868526
This study is looking at how certain immune cells help calm down lung inflammation caused by the flu, and it aims to find out how these cells work so we can better protect lungs during bad flu infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOUISIANA STATE UNIV A&M COL BATON ROUGE (nih funded) |
| Locations | 1 site (BATON ROUGE, UNITED STATES) |
| Trial ID | NIH-10868526 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific immune cells, known as regulatory CD8+ T cells, in managing lung inflammation caused by influenza infections. By using advanced techniques like ATAC sequencing, the study aims to identify the molecular mechanisms that allow these cells to produce an important cytokine, IL-10, which helps reduce harmful inflammation. The research involves both laboratory experiments and the use of a special mouse model that allows scientists to observe these immune cells in action. The ultimate goal is to improve our understanding of how to better control lung damage during severe flu infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who experience severe influenza infections or have a history of respiratory complications related to the flu.
Not a fit: Patients who do not suffer from influenza or have mild flu symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing severe lung damage in patients with influenza, potentially saving lives.
How similar studies have performed: While the role of CD4+ regulatory T cells is well-established, the specific focus on IL-10+ regulatory CD8+ T cells in the context of influenza is relatively novel, indicating a potential for groundbreaking findings.
Where this research is happening
BATON ROUGE, UNITED STATES
- LOUISIANA STATE UNIV A&M COL BATON ROUGE — BATON ROUGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, WEISHAN — LOUISIANA STATE UNIV A&M COL BATON ROUGE
- Study coordinator: HUANG, WEISHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.