Understanding how certain immune cells grow in lupus
Determinants of follicular helper T cell expansion in lupus
This study is looking at what causes certain immune cells to grow in people with lupus, which could help us understand the disease better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10881893 on NIH RePORTER |
What this research studies
This research investigates the factors that lead to the expansion of follicular helper T cells, which are important in the immune response and are linked to the severity of lupus. By using advanced cellular and molecular techniques, the study aims to uncover the genetic, microbial, and metabolic influences on these immune cells in lupus-prone mouse models. The findings could provide insights into how these cells contribute to the disease and potentially lead to new therapeutic strategies for patients with lupus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lupus, particularly those experiencing severe symptoms.
Not a fit: Patients with lupus who are in remission or have mild symptoms may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or even prevent the progression of lupus.
How similar studies have performed: Other research has shown promising results in understanding immune cell behavior in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Morel, Laurence — University of Texas Hlth Science Center
- Study coordinator: Morel, Laurence
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.