Understanding how certain immune cells develop in the thymus
γδTCR-dependent and independent differentiation of innate lymphoid cells
['FUNDING_R01'] · OKLAHOMA MEDICAL RESEARCH FOUNDATION · NIH-10890867
This study is looking at how certain immune cells, called innate lymphoid cells, develop in the thymus and how they help our body respond to different situations, which could help us understand our immune system better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OKLAHOMA MEDICAL RESEARCH FOUNDATION (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-10890867 on ClinicalTrials.gov |
What this research studies
This research investigates the differentiation of innate lymphoid cells (ILCs) in the thymus, which are crucial for immune responses. It aims to understand how these cells develop from T cell precursors and their functions in the body. By utilizing advanced techniques like single-cell RNA sequencing, the study will explore the presence of specific markers that indicate the origin of these cells. The findings could provide insights into how the immune system responds to various environmental cues.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with immune system disorders or those interested in understanding their immune health.
Not a fit: Patients with fully functional immune systems and no underlying immune conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in patients, particularly those with immune deficiencies or allergies.
How similar studies have performed: Previous research has shown promising results in understanding immune cell differentiation, suggesting that this approach could yield valuable insights.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- OKLAHOMA MEDICAL RESEARCH FOUNDATION — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, XIAO-HONG — OKLAHOMA MEDICAL RESEARCH FOUNDATION
- Study coordinator: SUN, XIAO-HONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.