Understanding how certain immune cells develop and respond over time
Integrative approaches defining the ontogeny, maintenance, and immune response dynamics of marginal-zone B cells
This study is looking at special immune cells called marginal zone B cells to see how they grow and work throughout our lives, especially as we age or face infections, which could help us understand why some people get sick more easily.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10923890 on NIH RePORTER |
What this research studies
This research investigates the role of marginal zone B cells, which are crucial for defending against infections. It aims to understand how these immune cells develop, maintain their numbers, and respond to pathogens throughout a person's life. By combining mathematical models with experimental techniques, the researchers will explore how aging and immune challenges affect these cells. This knowledge could help identify why some individuals are more susceptible to infections and autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old, particularly those with immune deficiencies or autoimmune conditions.
Not a fit: Patients who are under 21 years old or do not have any immune-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses and preventing infections in vulnerable populations.
How similar studies have performed: Previous research has shown promising results in understanding immune cell dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Rane, Sanket — Columbia Univ New York Morningside
- Study coordinator: Rane, Sanket
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.