Understanding how certain immune cells develop and respond over time
Official title: Integrative approaches defining the ontogeny, maintenance, and immune response dynamics of marginal-zone B cells
Funded at Columbia Univ New York Morningside · NIH-10923890 · Data updated 2026-11-12
This study is looking at special immune cells called marginal zone B cells to see how they grow and work throughout our lives, especially as we age or face infections, which could help us understand why some people get sick more easily.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 7, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $487,629 |
| NIH project number | 5R01AI170965-02 |
| Project ID | NIH-10923890 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old, particularly those with immune deficiencies or autoimmune conditions.
✕Less likely to help
Patients who are under 21 years old or do not have any immune-related issues may not benefit from this research.
What this research studies
This research investigates the role of marginal zone B cells, which are crucial for defending against infections. It aims to understand how these immune cells develop, maintain their numbers, and respond to pathogens throughout a person's life. By combining mathematical models with experimental techniques, the researchers will explore how aging and immune challenges affect these cells. This knowledge could help identify why some individuals are more susceptible to infections and autoimmune diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses and preventing infections in vulnerable populations.
How similar studies have gone: Previous research has shown promising results in understanding immune cell dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Rane, Sanket — Columbia Univ New York Morningside
- Study coordinator: Rane, Sanket
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.