Understanding how certain immune cells develop and function in humans
Official title: The molecular circuits controlling human T follicular regulatory cell development
Funded at Children's Hosp of Philadelphia · NIH-11049651 · Data updated 2026-11-12
This study is looking at special immune cells called T follicular regulatory (Tfr) cells to understand how they help protect against infections and prevent autoimmune diseases, specifically in people with common variable immunodeficiency (CVID).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | December 9, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $781,685 |
| NIH project number | 1R01AI179680-01A1 |
| Project ID | NIH-11049651 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with common variable immunodeficiency (CVID) or other autoimmune disorders.
✕Less likely to help
Patients without autoimmune conditions or immune deficiencies may not benefit from this research.
What this research studies
This research investigates the development and function of T follicular regulatory (Tfr) cells, which play a crucial role in guiding immune responses to pathogens while preventing autoimmunity. By examining lymph nodes from patients with common variable immunodeficiency (CVID), the study aims to uncover the molecular mechanisms that control these immune cells and how their dysfunction may lead to autoimmune diseases. The researchers will analyze the lineage of Tfr cells and their alterations in patients, providing insights into the relationship between immune deficiencies and autoimmune conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with autoimmune diseases and immune deficiencies.
How similar studies have gone: Previous research has shown promising results in understanding immune cell functions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Romberg, Neil David — Children's Hosp of Philadelphia
- Study coordinator: Romberg, Neil David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.