Understanding how certain immune cells develop and function in allergic diseases
Official title: Mechanism of Transcriptional Regulation of Th2 Cell Development
Funded at Icahn School of Medicine at Mount Sinai · NIH-11091441 · Data updated 2026-11-12
This study is looking at how certain proteins help immune cells called Th2 cells develop, which play a big role in allergies and conditions like asthma and eczema, to find new ways to improve treatments for people dealing with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 9, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $694,997 |
| NIH project number | 5R01AI177461-03 |
| Project ID | NIH-11091441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with asthma, atopic dermatitis, or other Th2-associated allergic conditions.
✕Less likely to help
Patients without allergic diseases or those with non-Th2 related immune disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the development of Th2 cells, a type of immune cell involved in allergic responses and inflammation. It focuses on how specific proteins and transcription factors regulate the differentiation of these cells from naive T cells, particularly in the context of conditions like asthma and atopic dermatitis. By exploring the role of BRD4 and its interactions with other proteins, the study aims to uncover new insights into the regulation of immune responses that lead to allergic diseases. Patients may benefit from a better understanding of their conditions and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from allergic diseases and asthma.
How similar studies have gone: Other research has shown success in understanding immune cell differentiation, but this specific approach to studying Th2 cell regulation is relatively novel.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Zhou, Ming-Ming — Icahn School of Medicine at Mount Sinai
- Study coordinator: Zhou, Ming-Ming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.