Understanding how certain immune cells control HIV without treatment
Characterizing ART-free NK cell-mediated control of HIV infection in people living with HIV
This study is looking at how some people with HIV can keep the virus in check without medication, focusing on special immune cells called Natural Killer (NK) cells, to help find new treatment options for everyone living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10671559 on NIH RePORTER |
What this research studies
This research investigates how some individuals living with HIV can control the virus without antiretroviral therapy (ART). It focuses on a specific type of immune cell called Natural Killer (NK) cells, which may have unique properties that allow them to suppress HIV rebound after treatment is stopped. By analyzing samples from individuals known as post-treatment controllers (PTCs), the study aims to identify the characteristics and functions of NK cells that contribute to this control. The findings could provide insights into potential new therapies for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have been identified as post-treatment controllers.
Not a fit: Patients who are not living with HIV or those who do not have the ability to control the virus after stopping ART may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing HIV without the need for continuous treatment.
How similar studies have performed: Previous research has shown promise in understanding immune responses in HIV, but this specific focus on NK cells in post-treatment controllers is relatively novel.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Roan, Nadia R — J. David Gladstone Institutes
- Study coordinator: Roan, Nadia R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.