Understanding how certain immune cells contribute to Type 1 Diabetes
The Origins of Human Anti-Insulin B Lymphocytes in Type 1 Diabetes
This study is looking at how certain immune cells called B lymphocytes might contribute to the development of Type 1 Diabetes by attacking the cells that produce insulin, and it hopes to find early signs in blood samples from people at risk for the disease to help improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10992135 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, known as B lymphocytes, in the development of Type 1 Diabetes (T1D). It focuses on how these cells interact with other immune cells to attack insulin-producing beta cells, potentially leading to diabetes. By analyzing blood samples from individuals at risk for T1D, the study aims to identify early biomarkers that could predict the onset of the disease. This could help in understanding the progression of T1D and in developing targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include children under 11 years old who are at risk for developing Type 1 Diabetes.
Not a fit: Patients who are already diagnosed with Type 1 Diabetes and are not in the pre-symptomatic phase may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of Type 1 Diabetes, improving outcomes for patients.
How similar studies have performed: Other research has shown promise in understanding autoimmune responses in diabetes, but this specific approach is novel and aims to fill critical knowledge gaps.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Bonami, Rachel H — Vanderbilt University Medical Center
- Study coordinator: Bonami, Rachel H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.