Understanding how certain immune cells contribute to rheumatoid arthritis
The role of cytotoxic T cells in rheumatoid arthritis pathogenesis
This study is looking at how certain immune cells might contribute to rheumatoid arthritis by causing the body to produce harmful antibodies, and it's inviting patients with a specific type of leukemia related to RA to help researchers understand these connections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10911995 on NIH RePORTER |
What this research studies
This research investigates the role of cytotoxic T cells in the development of rheumatoid arthritis (RA), particularly focusing on how these immune cells may lead to the production of harmful autoantibodies. The study examines the mechanisms behind the immune response to citrullinated proteins, which are implicated in RA pathogenesis. By analyzing patients with a specific type of leukemia that is associated with RA, the researchers aim to uncover the connections between these conditions and identify potential therapeutic targets. Patients may be involved in providing samples or data to help elucidate these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with rheumatoid arthritis, particularly those with severe symptoms or autoantibodies to citrullinated proteins.
Not a fit: Patients with rheumatoid arthritis who do not have autoantibodies or those with other forms of arthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or even prevent rheumatoid arthritis.
How similar studies have performed: Previous research has shown promising results in understanding the immune mechanisms involved in rheumatoid arthritis, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Andrade, Felipe — Johns Hopkins University
- Study coordinator: Andrade, Felipe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.