Understanding how certain immune cells contribute to organ damage in chronic graft versus host disease.
Role of macrophage polarization in multi-organ fibrosis of chronic GVHD
This study is looking at how certain immune cells called macrophages contribute to scarring in patients with chronic graft versus host disease after a stem cell transplant, and it aims to find new ways to help manage this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10684854 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, known as macrophages, in causing fibrosis, or scarring, in patients with chronic graft versus host disease (cGVHD) following stem cell transplants. The study focuses on how these macrophages can change their behavior to promote fibrosis and aims to identify the underlying mechanisms that drive this process. By using both mouse models and human tissue samples, the researchers will explore the signaling pathways involved in this immune response, particularly the hedgehog signaling pathway. The ultimate goal is to provide insights that could lead to new therapeutic strategies for managing cGVHD-related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone allogeneic hematopoietic stem cell transplantation and are experiencing symptoms of chronic graft versus host disease.
Not a fit: Patients who have not undergone stem cell transplantation or do not have chronic graft versus host disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce fibrosis and improve the quality of life for patients suffering from chronic graft versus host disease.
How similar studies have performed: Previous research has shown promising results in understanding immune cell behavior in similar conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Huang, Xiaopei — Ohio State University
- Study coordinator: Huang, Xiaopei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.