Understanding how certain immune cells contribute to lung transplant complications
Official title: Crosstalk between profibrotic monocyte-derived macrophages and T cells in the pathobiology of CLAD
Funded at Northwestern University at Chicago · NIH-10933925 · Data updated 2026-11-12
This study is looking at how certain immune cells might contribute to lung problems after a transplant, and it aims to find new ways to help lung transplant patients feel better by understanding these cells better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 17, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $412,764 |
| NIH project number | 1P01HL169188-01A1 |
| Project ID | NIH-10933925 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have undergone lung transplantation and are at risk of developing chronic lung allograft dysfunction.
✕Less likely to help
Patients who have not received a lung transplant or those with other unrelated chronic lung diseases may not benefit from this research.
What this research studies
This research investigates the role of specific immune cells, particularly profibrotic monocyte-derived macrophages, in the development of chronic lung allograft dysfunction (CLAD) after lung transplantation. By examining how these cells interact with T cells and other immune components, the study aims to identify potential biomarkers and therapeutic targets that could improve outcomes for lung transplant recipients. The research employs advanced mechanistic experiments to explore the signaling pathways involved in CLAD, which could lead to new treatment strategies. Patients may be involved in providing samples or data to help understand the disease better.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve survival rates and quality of life for lung transplant recipients.
How similar studies have gone: Previous research has shown promise in understanding immune cell interactions in other transplant settings, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Misharin, Alexander — Northwestern University at Chicago
- Study coordinator: Misharin, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.