Understanding how certain immune cells contribute to Kawasaki disease
Role of neutrophils and eosinophils in bacterial ligand-induced vasculitis
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-10903812
This study is looking at how certain immune cells, called neutrophils and eosinophils, affect Kawasaki disease in kids, with the hope of finding better treatments for those who don’t get better with regular medicine.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10903812 on ClinicalTrials.gov |
What this research studies
This research investigates the role of neutrophils and eosinophils in Kawasaki disease, a serious condition that can lead to heart problems in children. By studying a mouse model, the researchers aim to uncover how these immune cells contribute to inflammation and the development of coronary artery aneurysms. The study focuses on the production of a specific signaling molecule, IL-1β, which is believed to play a key role in the disease's progression. Insights gained from this research could lead to improved treatments for children who do not respond to standard therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Kawasaki disease, especially those who do not respond to intravenous immunoglobulin treatment.
Not a fit: Patients with Kawasaki disease who respond well to standard treatments may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for Kawasaki disease, particularly for patients who are resistant to current therapies.
How similar studies have performed: Other research has shown promise in targeting IL-1β signaling in similar inflammatory conditions, suggesting a potential for success in this approach.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARDITI, MOSHE — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: ARDITI, MOSHE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.