Understanding how certain immune cells contribute to Kawasaki disease
Official title: Role of neutrophils and eosinophils in bacterial ligand-induced vasculitis
Funded at Cedars-Sinai Medical Center · NIH-10903812 · Data updated 2026-11-12
This study is looking at how certain immune cells, called neutrophils and eosinophils, affect Kawasaki disease in kids, with the hope of finding better treatments for those who don’t get better with regular medicine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 23, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $582,362 |
| NIH project number | 5R01AI157274-05 |
| Project ID | NIH-10903812 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with Kawasaki disease, especially those who do not respond to intravenous immunoglobulin treatment.
✕Less likely to help
Patients with Kawasaki disease who respond well to standard treatments may not benefit directly from this research.
What this research studies
This research investigates the role of neutrophils and eosinophils in Kawasaki disease, a serious condition that can lead to heart problems in children. By studying a mouse model, the researchers aim to uncover how these immune cells contribute to inflammation and the development of coronary artery aneurysms. The study focuses on the production of a specific signaling molecule, IL-1β, which is believed to play a key role in the disease's progression. Insights gained from this research could lead to improved treatments for children who do not respond to standard therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for Kawasaki disease, particularly for patients who are resistant to current therapies.
How similar studies have gone: Other research has shown promise in targeting IL-1β signaling in similar inflammatory conditions, suggesting a potential for success in this approach.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Arditi, Moshe — Cedars-Sinai Medical Center
- Study coordinator: Arditi, Moshe
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.