Understanding how certain immune cells contribute to HIV persistence in the brain
The Role of Myeloid Cells in HIV Latency and Persistence in the Brain
['FUNDING_R01'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-10861091
This study is looking at how certain brain cells, called microglia, help keep the HIV virus hidden in people who are on treatment, with the hope of finding new ways to help cure HIV and improve brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-10861091 on ClinicalTrials.gov |
What this research studies
This research investigates the role of myeloid cells, particularly microglia, in maintaining HIV latency in the brain of individuals on antiretroviral therapy. By studying animal models and analyzing brain tissue, the researchers aim to identify how these cells harbor the virus and contribute to neurological disorders associated with HIV. The goal is to enhance strategies for curing HIV by targeting not just T cells but also these myeloid cells that may serve as reservoirs for the virus. This research could lead to a better understanding of HIV persistence and potential new treatment approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are on antiretroviral therapy and may be experiencing neurological symptoms.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative strategies for eradicating HIV from the body, improving health outcomes for individuals living with HIV.
How similar studies have performed: While there has been significant research on HIV latency, the specific focus on myeloid cells in the brain is a relatively novel approach that has not been extensively tested.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WAHL, ANGELA RAQUEL — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: WAHL, ANGELA RAQUEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus