Understanding how certain immune cells contribute to high blood pressure in the lungs caused by low oxygen levels.

Who could benefit from this research

What this research studies

This research investigates the role of classical dendritic cells in the development of hypoxia-induced pulmonary hypertension (HPH), a serious condition characterized by high blood pressure in the lungs due to low oxygen levels. The study focuses on how these immune cells interact with their environment and influence inflammation and vascular remodeling in the lungs. By analyzing the behavior of dendritic cells and their impact on other immune cells, the research aims to uncover new mechanisms that contribute to the disease. This could lead to better understanding and potential new treatments for patients suffering from HPH.

Why it matters

Where this research is happening

• University of Colorado Denver
  Aurora, United States Active

Researchers

• Principal investigator: Mickael, Claudia Silva — University of Colorado Denver
• Study coordinator: Mickael, Claudia Silva

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.