Understanding how certain immune cells contribute to high blood pressure in the lungs caused by low oxygen levels.
Novel Role of Classical Dendritic Cells in the pathogenesis of Hypoxia-Induced Pulmonary Hypertension
This study is looking at how certain immune cells in your body might affect high blood pressure in the lungs caused by low oxygen levels, with the hope of finding new ways to help people who have this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10914166 on NIH RePORTER |
What this research studies
This research investigates the role of classical dendritic cells in the development of hypoxia-induced pulmonary hypertension (HPH), a serious condition characterized by high blood pressure in the lungs due to low oxygen levels. The study focuses on how these immune cells interact with their environment and influence inflammation and vascular remodeling in the lungs. By analyzing the behavior of dendritic cells and their impact on other immune cells, the research aims to uncover new mechanisms that contribute to the disease. This could lead to better understanding and potential new treatments for patients suffering from HPH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hypoxia-induced pulmonary hypertension or those experiencing related symptoms.
Not a fit: Patients with pulmonary hypertension not related to hypoxia or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating hypoxia-induced pulmonary hypertension, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown that targeting immune responses can be effective in treating various forms of pulmonary hypertension, suggesting potential success for this approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Mickael, Claudia Silva — University of Colorado Denver
- Study coordinator: Mickael, Claudia Silva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.