Understanding how certain immune cells contribute to food allergies in children
Characterizing the IgG1 Memory B cells that are precursors of pathogenic IgE
This study is looking at how certain immune cells called memory B cells might contribute to food allergies, especially peanut allergies, and aims to find ways to help kids who have these allergies by understanding how these cells can produce harmful antibodies.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10896466 on NIH RePORTER |
What this research studies
This research investigates the role of specific memory B cells in the development of food allergies, particularly focusing on how these cells can switch to produce harmful IgE antibodies. Using mouse models of peanut allergy, the study aims to identify markers that differentiate between various subsets of these B cells. By understanding the signals that lead to the production of pathogenic IgE, the research seeks to uncover potential therapeutic targets that could improve treatment options for children suffering from food allergies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with food allergies, particularly peanut allergies.
Not a fit: Patients who do not have food allergies or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively manage or even prevent food allergies in children.
How similar studies have performed: Previous research has shown promise in understanding immune responses related to allergies, but this specific approach focusing on IgG memory B cells is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Redes, Jamie — Icahn School of Medicine at Mount Sinai
- Study coordinator: Redes, Jamie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.