Understanding how certain immune cells contribute to allergic asthma
Official title: Lipid shuttling in memory Th2 cell fate and function in allergic asthma
Funded at Massachusetts General Hospital · NIH-10738803 · Data updated 2026-11-12
This study is looking at how certain immune cells that help cause allergic asthma work and how a specific protein affects them, with the goal of finding new ways to treat people who suffer from this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | November 10, 2022 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $252,000 |
| NIH project number | 5R21AI173732-02 |
| Project ID | NIH-10738803 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with allergic asthma, particularly those who experience recurrent symptoms upon allergen exposure.
✕Less likely to help
Patients with non-allergic asthma or those whose asthma is not driven by Th2 cell responses may not benefit from this research.
What this research studies
This research investigates the development and function of memory Th2 cells, which are crucial in driving allergic asthma. By studying how these cells respond to allergens and the role of a specific transcription factor called PPARg in their metabolism, the research aims to uncover new therapeutic targets. The approach involves using murine models to analyze the mechanisms behind these immune responses, potentially leading to innovative treatments for patients with allergic asthma.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively manage or prevent allergic asthma symptoms.
How similar studies have gone: Previous research has shown promising results in targeting immune cell functions in asthma, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Rahimi, Rod Amir — Massachusetts General Hospital
- Study coordinator: Rahimi, Rod Amir
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.