Understanding how certain immune cells change in response to a virus
Characterizing single cell states of activated and transformed B cells in rhesus macaque models
This study is looking at how the Epstein-Barr virus affects important immune cells called B cells in monkeys, hoping to find early signs of cancer and better ways to diagnose and treat related diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10799690 on NIH RePORTER |
What this research studies
This research investigates how the Epstein-Barr virus (EBV) affects B cells, which are crucial components of the immune system. By studying rhesus macaque models, the researchers aim to identify specific markers and molecular signatures that indicate early cancer development and B cell transformation. The approach involves advanced techniques to analyze individual cells, allowing for a detailed understanding of how the virus alters these immune cells. This knowledge could lead to improved diagnostics and therapies for diseases related to EBV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital or acquired immune deficiencies who are at risk for EBV-related diseases.
Not a fit: Patients without immune deficiencies or those not affected by EBV-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for patients with EBV-related diseases, including certain cancers.
How similar studies have performed: Previous research has shown promise in understanding viral impacts on immune cells, but this specific approach using single-cell analysis in a pre-clinical model is relatively novel.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Skalsky, Rebecca L — Oregon Health & Science University
- Study coordinator: Skalsky, Rebecca L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.