Understanding how certain immune cells can protect against different strains of influenza virus
Heterosubtypic immunity to influenza virus mediated by MHC-E-restricted memory NK cells
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-10908380
This study is looking at how special immune cells called Natural Killer (NK) cells can help protect us from different types of the flu virus, and it aims to find ways to make better vaccines that keep us safe for longer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10908380 on ClinicalTrials.gov |
What this research studies
This research investigates how specific immune cells, known as Natural Killer (NK) cells, can provide protection against various strains of the influenza virus. The study focuses on the ability of these NK cells to remember past infections and respond effectively to new, antigenically distinct strains. By exploring the mechanisms behind this immune memory, the research aims to develop innovative strategies for creating more effective vaccines that offer broader and longer-lasting protection against influenza. Patients may benefit from insights that could lead to improved vaccination strategies and better overall protection against seasonal and pandemic influenza.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who are interested in influenza vaccination and immune response.
Not a fit: Patients who are not interested in influenza vaccination or who have contraindications to receiving vaccines may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines that provide broader protection against influenza viruses.
How similar studies have performed: Other research has shown promising results in enhancing immune responses through innovative approaches, making this area of investigation both relevant and potentially impactful.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOST, STEPHANIE — DUKE UNIVERSITY
- Study coordinator: JOST, STEPHANIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.