Understanding how certain immune cells can promote tolerance in the body
Official title: Molecular control of tolerogenic dendritic cell function
Funded at New York University School of Medicine · NIH-11058010 · Data updated 2026-11-12
This study is looking at special immune cells called dendritic cells to see how they help keep our immune system balanced and prevent autoimmune diseases, with the hope of finding new ways to help people manage these conditions better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | November 20, 2024 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $246,623 |
| NIH project number | 1R21AI182549-01A1 |
| Project ID | NIH-11058010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune diseases or those at risk of developing such conditions.
✕Less likely to help
Patients with non-autoimmune conditions or those who do not have any immune-related issues may not benefit from this research.
What this research studies
This research investigates the role of dendritic cells, which are crucial for initiating immune responses, in maintaining immune tolerance and preventing autoimmune diseases. The study aims to identify the specific dendritic cell subsets that promote tolerance and to understand the molecular mechanisms that control their function. By examining how these cells can switch between promoting immunity and tolerance, the research seeks to uncover potential therapeutic targets for autoimmune conditions. Patients may benefit from insights gained about how to better regulate immune responses in various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases by enhancing the body's ability to maintain immune tolerance.
How similar studies have gone: Previous research has shown promising results in understanding dendritic cell functions, but this specific approach to targeting tolerogenic mechanisms is relatively novel.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Reizis, Boris — New York University School of Medicine
- Study coordinator: Reizis, Boris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.