Understanding how certain immune cells can help cure HIV
Official title: Characterization of Allogeneic T Cells Mediating HIV Cure
Funded at Oregon Health & Science University · NIH-11191791 · Data updated 2026-11-12
This study is looking at how certain immune cells from donors might help people who have had a stem cell transplant get rid of HIV, and it aims to find new ways to treat the virus for those living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | June 16, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $1,657,972 |
| NIH project number | 1R01AI189285-01A1 |
| Project ID | NIH-11191791 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who have not responded to traditional antiretroviral therapies and are considering or have undergone alloSCT.
✕Less likely to help
Patients who are not living with HIV or those who have not undergone alloSCT may not benefit from this research.
What this research studies
This research investigates the role of allogeneic T cells in potentially curing HIV by eliminating the viral reservoir in patients. It focuses on individuals who have successfully undergone allogeneic hematopoietic stem cell transplantation (alloSCT) and examines how their immune responses can target and eradicate HIV. The study will analyze T cell responses in both cured individuals and animal models to identify effective strategies for achieving a functional cure for HIV. Patients may benefit from insights that could lead to new treatment options for HIV.
Why it matters
Potential benefit: If successful, this research could lead to a functional cure for HIV, significantly improving the lives of those living with the virus.
How similar studies have gone: Previous cases of individuals cured of HIV following alloSCT suggest that this approach has potential, although the specific mechanisms are still being explored.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Sacha, Jonah B. — Oregon Health & Science University
- Study coordinator: Sacha, Jonah B.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.