Understanding how certain immune cells can be kept active against viruses
Mechanisms of T Cell Quiescence and Exhaustion
This study is looking at how certain immune cells, called TCF1Hi stem-like CD8 T cells, can help fight off long-lasting viral infections while keeping your body safe, and it aims to find new ways to boost these cells' abilities to help people dealing with chronic viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10995348 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind T cell quiescence and exhaustion, focusing on a specific type of immune cell known as TCF1Hi stem-like CD8 T cells. These cells are crucial for controlling viral infections while minimizing damage to the body. The study aims to identify the signals that promote the generation of these cells during chronic viral infections and to develop new therapies that enhance their function. By exploring the relationship between IL-2 signals and PD-1, the research seeks to create innovative treatments for patients with persistent viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic viral infections, such as those living with HIV/AIDS.
Not a fit: Patients with acute viral infections or those without any viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with chronic viral infections, enhancing their immune response and overall health.
How similar studies have performed: Other research has shown promising results in enhancing immune responses through similar approaches, indicating potential for success in this area.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Sarkar, Surojit — Seattle Children's Hospital
- Study coordinator: Sarkar, Surojit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.