Understanding how certain immune cells behave in acute myeloid leukemia
Group 1 Innate Lymphoid Cell Dysregulation in Acute Myeloid Leukemia
This study is looking at how a type of immune cell called natural killer (NK) cells is affected by acute myeloid leukemia (AML) and aims to find new ways to boost the body's immune response to help fight the cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10994614 on NIH RePORTER |
What this research studies
This research investigates the role of innate lymphoid cells, particularly natural killer (NK) cells, in acute myeloid leukemia (AML). It aims to understand how AML affects the maturation and function of these immune cells, which are crucial for fighting cancer. The researchers will explore the mechanisms by which AML cells inhibit NK cell activity and promote the expansion of other immune cell types that may support tumor growth. By studying these interactions, the research seeks to identify new therapeutic strategies to enhance immune responses against AML.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia who may benefit from new therapeutic approaches.
Not a fit: Patients with other types of leukemia or those who are not diagnosed with acute myeloid leukemia may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve survival rates for patients with acute myeloid leukemia.
How similar studies have performed: Other research has shown promising results in understanding immune cell interactions in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Lordo, Matthew — Ohio State University
- Study coordinator: Lordo, Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.