Understanding how certain immune cells are recruited and retained in the colon
Official title: The recruitment and retention of colon intraepithelial lymphocytes
Funded at University of Colorado Denver · NIH-10996624 · Data updated 2026-11-12
This study is looking at how certain immune cells in the colon help keep your gut healthy and prevent inflammation, especially when dealing with bacteria, which could be helpful for people with conditions like inflammatory bowel disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $37,659 |
| NIH project number | 1F31DK138543-01A1 |
| Project ID | NIH-10996624 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inflammatory bowel disease or those experiencing gastrointestinal issues related to intestinal barrier dysfunction.
✕Less likely to help
Patients without gastrointestinal conditions or those who do not have issues related to intestinal barrier integrity may not benefit from this research.
What this research studies
This research investigates the role of colon intraepithelial lymphocytes (cIELs) in maintaining the intestinal barrier and preventing inflammation. It focuses on how these immune cells are recruited to and retained in the epithelial layer of the colon, particularly in response to luminal bacteria. The study employs various experimental techniques to explore the signaling pathways involved, including the role of myeloid cells and specific signaling molecules. By understanding these mechanisms, the research aims to shed light on the immune response in the colon and its implications for conditions like inflammatory bowel disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating inflammatory bowel diseases by enhancing intestinal barrier function.
How similar studies have gone: Previous research has shown success in understanding immune cell functions in the gut, but this specific focus on cIELs and their recruitment mechanisms is relatively novel.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Danielson, Sarah Mann — University of Colorado Denver
- Study coordinator: Danielson, Sarah Mann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.