Understanding how certain immune cells affect skin allergies
Elucidating the Role of Regulatory T cells in Establishing and Maintaining a Th2 Niche in Skin
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10878009
This study is looking at how certain immune cells in the skin help keep allergies at bay, using baby mice to learn what happens when these cells are missing, which could help us find new treatments for skin allergies like atopic dermatitis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10878009 on ClinicalTrials.gov |
What this research studies
This research investigates the role of regulatory T cells in the skin, particularly how they help establish and maintain a specific environment that prevents allergic reactions. By studying neonatal mice, the researchers aim to understand how the loss of these immune cells can lead to an increase in allergic responses later in life. The approach involves examining the interactions between different immune cells and the skin's microenvironment, which could provide insights into treating conditions like atopic dermatitis. Patients may benefit from findings that could lead to new therapies for skin allergies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of allergic skin conditions, particularly those who developed symptoms in childhood.
Not a fit: Patients with non-allergic skin conditions or those who do not have a history of immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for allergic skin conditions, improving the quality of life for affected patients.
How similar studies have performed: Previous research has shown that understanding immune cell interactions can lead to significant advancements in treating allergic conditions, suggesting that this approach has potential for success.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROSENBLUM, MICHAEL DAVID — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: ROSENBLUM, MICHAEL DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.