Understanding how certain immune cells affect severe viral lung infections in children
Official title: Myeloid-derived suppressor cells modulate disease severity in children with viral lower respiratory tract infections
Funded at Research Inst Nationwide Children's Hosp · NIH-10984694 · Data updated 2026-11-12
This study is looking at how certain immune cells in kids with severe viral lung infections might be making it harder for their bodies to fight off the illness, with the hope of finding new ways to help them recover better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $180,199 |
| NIH project number | 1K23HL171862-01A1 |
| Project ID | NIH-10984694 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who are experiencing severe viral lower respiratory tract infections.
✕Less likely to help
Patients with mild viral infections or those over 11 years old may not benefit from this research.
What this research studies
This research investigates the role of myeloid-derived suppressor cells (MDSC) in children suffering from severe viral lower respiratory tract infections (LRTI). The study aims to understand how these immune cells may inhibit the body's ability to fight off infections and how they relate to the severity of the disease. By analyzing blood samples from affected children, researchers hope to uncover mechanisms that could lead to new treatments that enhance the immune response. The ultimate goal is to identify potential therapeutic targets that could improve outcomes for these young patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune response in children with severe viral lung infections, potentially reducing mortality and improving recovery.
How similar studies have gone: Previous research has shown promising results in adult populations regarding the modulation of MDSC for improving treatment outcomes, suggesting potential for success in pediatric cases as well.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Bline, Katherine — Research Inst Nationwide Children's Hosp
- Study coordinator: Bline, Katherine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.