Understanding how certain immune cells affect nerve healing after injury
Official title: The contribution of macrophage subpopulations to axon degeneration, nerve inflammation, and regeneration of the injured sciatic nerve
Funded at University of Michigan at Ann Arbor · NIH-11105759 · Data updated 2026-11-12
This study is looking at how certain immune cells called macrophages help heal injured nerves, especially the sciatic nerve, and aims to find ways to improve recovery and reduce pain for people with nerve injuries.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 1, 2024 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $40,060 |
| NIH project number | 5F31NS135919-02 |
| Project ID | NIH-11105759 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced traumatic injuries to their peripheral nerves, particularly those affecting the sciatic nerve.
✕Less likely to help
Patients with central nervous system injuries or those without nerve injuries may not receive any benefit from this research.
What this research studies
This research investigates the role of specific immune cells, known as macrophages, in the healing process of injured peripheral nerves, particularly the sciatic nerve. It focuses on how these cells contribute to the removal of damaged tissue and promote nerve regeneration. By analyzing the behavior of different macrophage subpopulations, the study aims to uncover mechanisms that could enhance nerve repair and reduce complications like neuropathic pain. Patients may benefit from insights that could lead to improved treatments for nerve injuries.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance nerve regeneration and reduce pain following nerve injuries.
How similar studies have gone: Previous research has shown promising results in understanding the role of macrophages in nerve repair, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Hafner, Hannah Jule — University of Michigan at Ann Arbor
- Study coordinator: Hafner, Hannah Jule
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.