Understanding how certain immune cells affect intestinal health and disease
Official title: A T cell STAT3-BATF axis regulates intestinal gamma delta T cell homeostasis and disease
Funded at Purdue University · NIH-10804693 · Data updated 2026-11-12
This study is looking at how certain immune cells interact in people with inflammatory bowel disease (IBD) to better understand how to create new treatments that can help manage the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | March 10, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $183,614 |
| NIH project number | 5R21AI176326-02 |
| Project ID | NIH-10804693 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including conditions like Crohn's disease and ulcerative colitis.
✕Less likely to help
Patients with non-inflammatory gastrointestinal disorders or those without a diagnosis of inflammatory bowel disease may not benefit from this research.
What this research studies
This research investigates the role of specific immune cell interactions in inflammatory bowel disease (IBD), a condition characterized by chronic inflammation of the intestines. The study aims to identify the mechanisms that regulate these immune interactions, particularly focusing on T cells that can either promote or suppress inflammation. By using mouse models that mimic human IBD, the researchers will explore how the STAT3 and BATF proteins influence these immune responses. The ultimate goal is to develop more effective therapies for patients suffering from IBD by targeting these cellular interactions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with inflammatory bowel disease, enhancing their quality of life and disease management.
How similar studies have gone: Previous research has shown promise in understanding immune interactions in IBD, but this specific approach focusing on the STAT3-BATF axis is relatively novel.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Olson, Matthew R — Purdue University
- Study coordinator: Olson, Matthew R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.