Understanding how certain immune cells affect HIV persistence and rebound
Determining the relative contribution of CD4 T cells and macrophages to HIV persistence and rebound
This study is looking at how certain immune cells, called CD4 T cells and macrophages, help HIV stick around even when people are on treatment, and it uses a monkey model to learn more about this so we can find better ways to help people with HIV stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10897101 on NIH RePORTER |
What this research studies
This research investigates the role of CD4 T cells and macrophages in the persistence of HIV despite antiretroviral therapy (ART). By using a model of SIV infection in rhesus macaques, the study aims to manipulate the size and distribution of viral reservoirs in these immune cells to understand how they contribute to HIV rebound after treatment interruption. The findings could provide insights into the mechanisms behind HIV persistence and inform new therapeutic strategies for achieving viral remission.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and may be interested in understanding the mechanisms of HIV persistence.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help eradicate HIV or maintain long-term viral remission in patients.
How similar studies have performed: While the approach of manipulating immune cell reservoirs is innovative, previous studies have shown some success in understanding HIV persistence, indicating potential for breakthroughs in this area.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Paiardini, Mirko — Emory University
- Study coordinator: Paiardini, Mirko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.