Understanding how certain immune cells affect healing in spinal cord injuries
Exploring the therapeutic mechanisms of proinflammatory myelin-laden macrophages retention in the injured spinal lesion core
This study looks at how certain immune cells can slow down healing after a spinal cord injury, and it hopes to find new ways to help improve recovery for people with these injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project ID | NIH-11030752 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, known as proinflammatory myelin-laden macrophages, in the healing process following spinal cord injuries. It focuses on how these cells accumulate in the injury site and hinder the growth of nerve fibers, which is crucial for recovery. By examining the mechanisms that lead to their retention and the impact on tissue regeneration, the study aims to uncover potential therapeutic targets. Patients may benefit from insights that could lead to improved treatments for spinal cord injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced spinal cord injuries, particularly those in the acute or chronic phases of recovery.
Not a fit: Patients with spinal cord injuries who are not in the acute or chronic phases, or those with other unrelated conditions, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance recovery and nerve regeneration in patients with spinal cord injuries.
How similar studies have performed: Previous research has shown promising results in understanding immune cell behavior in spinal cord injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
Tallahassee, United States
- Florida State University — Tallahassee, United States (Active)
Researchers
- Principal investigator: Ren, Yi — Florida State University
- Study coordinator: Ren, Yi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.