Understanding how certain immune cells affect gut nerve function
Role of Muscularis Macrophages in the Enteric Nervous System
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-10884511
This study is looking at how certain immune cells in the gut help support nerve cells that control digestion, especially as we age or deal with digestive issues like constipation, and it hopes to find new ways to improve gut health by working with patients to learn more about these cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10884511 on ClinicalTrials.gov |
What this research studies
This research investigates the role of muscularis macrophages, a type of immune cell, in the development and maintenance of enteric neurons, which are crucial for controlling gastrointestinal motility. The study aims to identify the mechanisms that regulate the interaction between these macrophages and enteric neurons, particularly in the context of digestive diseases and aging. By characterizing these immune cells in humans, the research seeks to uncover potential therapeutic targets for improving gut health and treating conditions like constipation. Patients may be involved in providing tissue samples to help understand these cellular interactions better.
Who could benefit from this research
Good fit: Ideal candidates for participation are adults experiencing digestive issues, particularly those with conditions like slow transit constipation.
Not a fit: Patients with digestive diseases unrelated to enteric neuron function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for digestive diseases by targeting the interactions between immune cells and gut nerves.
How similar studies have performed: Other research has shown promising results in understanding immune cell interactions in the gut, suggesting potential for success in this area as well.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CIPRIANI, GIANLUCA — MAYO CLINIC ROCHESTER
- Study coordinator: CIPRIANI, GIANLUCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.