Understanding how certain immune cells affect glioblastoma progression
Role of myeloid-derived suppressor cells in local and systemic immunosuppression in glioblastoma
This study is looking at how certain immune cells called myeloid-derived suppressor cells (MDSCs) affect glioblastoma, a tough brain cancer, and how these cells might differ between men and women, with the hope of finding better ways to help patients respond to treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11046531 on NIH RePORTER |
What this research studies
This research investigates the role of myeloid-derived suppressor cells (MDSCs) in glioblastoma, a highly aggressive brain tumor. It aims to understand how different types of MDSCs contribute to the tumor's ability to evade the immune system and promote its growth. By examining the variations in MDSC populations between male and female patients, the study seeks to uncover potential therapeutic targets that could enhance the effectiveness of existing treatments. Patients may benefit from insights that could lead to improved immunotherapy strategies tailored to their specific immune profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma, particularly those who may not have responded well to current therapies.
Not a fit: Patients with glioblastoma who are not eligible for immunotherapy or those with other types of brain tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma by targeting the immune suppression caused by MDSCs.
How similar studies have performed: Previous research has shown that targeting immune suppression in tumors can improve treatment outcomes, suggesting that this approach may hold promise.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Bayik Watson, Defne — University of Miami School of Medicine
- Study coordinator: Bayik Watson, Defne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.