Understanding how certain immune cells affect cancer treatment
Deciphering the molecular control of intratumoral dendritic cells
This study is looking at how certain immune cells called dendritic cells can help make cancer treatments, like anti-PD-1 therapy, work better by figuring out which genes control these cells, and it’s for anyone interested in improving cancer treatment outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11010828 on NIH RePORTER |
What this research studies
This research investigates the role of dendritic cells in tumor immunity, particularly how they influence the effectiveness of anti-PD-1 immunotherapy. By analyzing tumor samples from both humans and mice, the researchers aim to identify specific genes that regulate these immune cells. The goal is to find ways to enhance the ability of dendritic cells to stimulate an immune response against tumors, potentially improving treatment outcomes for patients receiving immunotherapy. The study employs advanced techniques like single-cell RNA sequencing to gain insights into the molecular mechanisms at play.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with tumors that are being treated with anti-PD-1 immunotherapy.
Not a fit: Patients who do not have tumors or are not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapy strategies that enhance the body's ability to fight cancer.
How similar studies have performed: Previous research has shown promising results in enhancing tumor immunity through the manipulation of dendritic cells, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Merad, Miriam — Icahn School of Medicine at Mount Sinai
- Study coordinator: Merad, Miriam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.