Understanding how certain immune cells affect breast cancer growth
Defining the contributions of Lyve-1 expressing macrophages to breast cancer growth and progression
This study is looking at how certain immune cells called macrophages help breast cancer grow and spread, using mice to learn more about their role and checking human samples to see if the same things happen in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11041075 on NIH RePORTER |
What this research studies
This research investigates the role of specific macrophage populations in the growth and progression of breast cancer. By using mouse models, the study aims to identify how these immune cells interact with the tumor environment and contribute to cancer invasion. The researchers will also explore the mechanisms by which these macrophages remodel the extracellular matrix, which may facilitate tumor development. Additionally, the study will examine the presence of these macrophages in human breast cancer samples to validate their findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those with aggressive forms of the disease.
Not a fit: Patients with non-breast cancer-related conditions or those who are not currently diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting macrophages to inhibit breast cancer progression.
How similar studies have performed: Previous research has shown that targeting immune cell interactions in tumors can lead to significant advancements in cancer treatment, suggesting a promising avenue for this study.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Schwertfeger, Kathryn L — University of Minnesota
- Study coordinator: Schwertfeger, Kathryn L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.