Understanding how certain human factors affect rhinovirus infections
Host Factors for Rhinovirus
This study is looking at how a protein called STING in our bodies affects the way certain stronger strains of the rhinovirus, which can make breathing difficult for people with asthma, multiply and cause problems, with the goal of finding better ways to prevent and treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11065443 on NIH RePORTER |
What this research studies
This research investigates the role of specific host factors, particularly the STING protein, in the replication of more virulent strains of rhinovirus, which are known to cause severe respiratory issues, especially in individuals with underlying lung conditions like asthma. The study aims to explore how different genetic variants of the STING protein influence the severity of rhinovirus infections and asthma exacerbations. By examining the interactions between the virus and host factors, the research seeks to uncover mechanisms that could lead to better prevention and treatment strategies for those affected by these infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with asthma or chronic obstructive pulmonary disease who experience frequent respiratory infections.
Not a fit: Patients without underlying respiratory conditions or those who do not experience rhinovirus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for patients suffering from severe respiratory infections and asthma exacerbations caused by rhinoviruses.
How similar studies have performed: Previous research has shown that understanding host factors in viral infections can lead to significant advancements in treatment, suggesting that this approach has potential for success.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Swanson, Karen V — Univ of North Carolina Chapel Hill
- Study coordinator: Swanson, Karen V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.