Understanding how certain HIV-1 structures can be targeted by specific antibodies
Characterizing HIV-1 Env conformations susceptible to attack by non-neutralizing antibodies
This study is looking at how certain antibodies in our immune system can help fight HIV by targeting specific parts of the virus, especially when it comes back after being hidden, and it hopes to find new ways to treat or even cure HIV infection based on past vaccine research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10737642 on NIH RePORTER |
What this research studies
This research investigates the structures of the HIV-1 virus that can be attacked by non-neutralizing antibodies, which are a type of immune response. The study focuses on how these antibodies can help eliminate HIV-infected cells, especially after the virus has been reactivated. By analyzing data from previous vaccine trials, the research aims to identify the mechanisms that allow for a strong immune response, potentially leading to new treatments that could eradicate or functionally cure HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and may be interested in new treatment options.
Not a fit: Patients who are not living with HIV or those who have advanced AIDS with significant immune system damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively eliminate HIV from the body or significantly improve the immune response in patients living with HIV.
How similar studies have performed: Previous vaccine trials, such as the RV144 trial in Thailand, have shown some success in generating protective immune responses, suggesting that this approach may hold promise.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Munro, James B — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Munro, James B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.