Understanding how certain heart cells help zebrafish regenerate their hearts
Official title: Uncovering the Role of Neural Crest Gene Regulatory Networks in Cardiac Regeneration
Funded at University of California Berkeley · NIH-10998900 · Data updated 2026-11-12
This study is looking at how certain heart cells in zebrafish help them heal their hearts after injury, and by understanding this process, we hope to find new ways to help people with heart problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,654 |
| NIH project number | 1F31HL176141-01 |
| Project ID | NIH-10998900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiac conditions who are interested in innovative treatment approaches.
✕Less likely to help
Patients with non-cardiac conditions or those who do not have regenerative heart issues may not benefit from this research.
What this research studies
This research investigates the role of neural crest-derived cardiomyocytes in the heart regeneration process of zebrafish, which can regenerate a significant portion of their hearts after injury. By using advanced techniques like single-cell genomics and transgenic manipulations, the study aims to identify how these specific heart cells contribute to regeneration. The findings could provide insights into the mechanisms behind heart regeneration, which is limited in humans. This research could pave the way for developing new therapies for heart diseases in humans by understanding the regenerative capabilities of these cells.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in heart regeneration therapies for patients with cardiac diseases.
How similar studies have gone: Previous research has shown promising results in understanding heart regeneration in animal models, indicating potential for success in this area.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Haugan, Alexandra K — University of California Berkeley
- Study coordinator: Haugan, Alexandra K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.