Understanding how certain gut bacteria contribute to colorectal cancer recurrence after surgery.
Elucidating the role and mechanisms by which collagenase producing intestinal bacteria promote colorectal cancer recurrence and metastasis following surgery.
This study is looking at how certain bacteria in the gut, especially one called Enterococcus faecalis, might affect the chances of colorectal cancer coming back after surgery, and it also explores how a high-fat diet could play a role, with the goal of finding better ways to help patients recover and make healthier eating choices.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11005722 on NIH RePORTER |
What this research studies
This research investigates the role of collagenase-producing bacteria in the recurrence of colorectal cancer (CRC) following surgical treatment. It focuses on how these bacteria, particularly Enterococcus faecalis, interact with the body's tissues and influence cancer progression after surgery. By studying the effects of a high-fat diet on gut microbiota and its implications for CRC recurrence, the research aims to uncover new strategies for prevention and treatment. Patients may benefit from insights that could lead to improved post-surgical care and dietary recommendations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone surgery for colorectal cancer and are at risk for recurrence.
Not a fit: Patients who have not had colorectal cancer or those whose cancer has not been surgically treated may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing colorectal cancer recurrence, potentially improving survival rates for patients.
How similar studies have performed: Other research has indicated that gut microbiota plays a significant role in cancer progression, suggesting that this approach may yield valuable insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Shogan, Benjamin — University of Chicago
- Study coordinator: Shogan, Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.